Search Results - antigen-binding+fragment

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Chimeric Antigen Receptors to CD276 for Treating Cancer
Abstract: Chimeric antigen receptors (CARs) are hybrid proteins consisting of an antibody binding fragment fused to protein signaling domains that cause T-cells which express the CAR to become cytotoxic.  Once activated, these cytotoxic T-cells can selectively eliminate the cells which they recognize via the antibody binding fragment of the CAR.  By...
Published: 4/8/2024   |   Inventor(s): Crystal Mackall, Yongzhi Cui
Keywords(s): adoptive cell therapy, ANTIBODY, antigen-binding fragment, CAR, Neuroblastoma
Category(s): Application > Therapeutics, Collaboration Sought > Licensing, TherapeuticArea > Oncology
Single Domain Antibodies (Nanobodies) Targeting SARS-CoV-2 for treating COVID-19
Abstract: The COVID-19 pandemic is a worldwide public health crisis with over 100 million confirmed cases and 2.4 million deaths as of February 2021. COVID-19 is caused by a novel coronavirus called SARS-CoV-2. SARS-COV-2 infects hosts via its spike (S) protein. The S protein contains the receptor binding domain (RBD) that binds to the angiotensin converting...
Published: 5/21/2024   |   Inventor(s): Mitchell Ho, Jessica Hong
Keywords(s): ANTIBODY, antigen-binding fragment, CORONAVIRUS, COVID-19, HO, NANOBODY, respiratory INFECTION, S Protein, SARS-CoV-2, spike protein
Category(s): TherapeuticArea > Infectious Disease, Collaboration Sought > Licensing, Collaboration Sought > Collaboration, Application > Therapeutics