Aging is a complicated multi-factorial process for which intervention remain a scientific challenge. Our researchers tested administration of a novel synthetic ketone diester (KDE), R/S 1,3-butanediol acetoacetate diester, in a mouse model of atrophy disease (Cancer anorexia cachexia syndrome; CACS) and in a mouse model of cancer-independent multifactorial inflammation-induced atrophy of lipopolysaccharide (LPS)-induced sepsis. They discovered that KDE administration promoted multiple pro-healthspan, pro-lifespan, and anti-aging effects: anti-tumor, anti-catabolic, anti-anorexia, metabolic regulation, while keeping pro-aging hormone insulin and IGF-1 suppressed.
This research demonstrates that ketone bodies can induce anti-catabolic effects and may support anti-aging treatments as well as improve patient outcomes across various multifaceted diseases including cancer, CACS, and sepsis.
Ketone Supplementation in an inflammation induced atrophy environment of LPS-induced sepsis (cancer independent model): KDE administration in mice reduced body weight loss (left: after 24 hours; right: up to 13 days after)