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Prevention of Head and Neck Cancer Using Rapamycin and Its Analogs
Case ID:
TAB-1895
Web Published:
12/6/2022
It is frequently observed in head and neck squamous cell carcinoma (HNSCC), a cancer occurring mostly in the mouth, that the Akt/mTOR pathway is abnormally activated. Therefore, inhibiting this signaling pathway may help in treating this disease. Rapamycin and its analogs are known to inhibit the activity of mTOR so in principle they could serve as therapeutics for treating HNSCC.
Researchers at the NIH have developed a method of potentially preventing or treating HNSCC through the inhibition of mTOR activity. The proof of this principle was demonstrated by rapid regression of mouth tumors in mice afflicted with Cowden syndrome with the administration of rapamycin. Like HNSCC, development of this disease is linked to over activation of the Akt/mTOR pathway. Furthermore, the therapeutic potential of rapamycin was demonstrated using mice in experiments that model chronic exposure to tobacco, which promotes the development of HNSCC. Therefore, inhibitors of mTOR have considerable potential in the prevention and treatment of HNSCC.
Patent Information:
Title
App Type
Country
Serial No.
Patent No.
File Date
Issued Date
Expire Date
Direct Link:
https://canberra-ip.technologypublisher.com/tech/Prevention_of_Head_and_Neck_ Cancer_Using_Rapamycin_and_Its_Analogs
Keywords:
(4)r syndrome
C syndrome
Carcinoma
CBXXXX
CHEMOPREVENTIVE
Chromosome 4 ring syndrome
Chromosome 6 ring syndrome
Chromosome 7 ring syndrome
Cowden's disease
Cowden's syndrome
CXXXXX
G syndrome
HEAD
Hypertelorism with esophageal abnormality and hypospadias
Listed LPM Campbell as of 4/15/2015
MTOR-inhibitors
N syndrome
NECK
Patent Category - Biotechnology
Patent Category - Chemistry
Post LPM Assignment Set 20150420
Pre LPM working set 20150418
R(6) syndrome
R(7) syndrome
Rapamycin
SQUAMOUS
Squamous cell carcinoma
Syndrome X
W syndrome
W syndrome; Syndrome W
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For Information, Contact:
Vladimir Knezevic
Senior Advisor for Commercial Evaluations
NIH Technology Transfer
vlado.knezevic@nih.gov