Functionalized Dendrimers with Regioselective Reactivity

Novel compositions of zwitterionic dendrimers and derived polymers

BACKGROUND:

There is a strong need for new classes of reactive reagents for the generation of novel materials with pre-defined characteristics.  Here, new compounds can be generated employing properties associated with zwitterions, dendrimers, or combination materials.

TECHNOLOGY OVERVIEW:

This University at Buffalo invention creates a new class of dendrimers with two integrated and novel features called zwitterionic dendrimers (ZDs).  The first is a zwitterion-functionalized outer layer, and the second is regioselective reactivity via focal reactive groups.  Reactions between the focal reactive groups of the dendrimers and reactive groups of secondary polymers can derive novel copolymers.  Structural design of resulting zwitterionic dendrimers, methods of synthesis, and reactions incorporating the zwitterionic dendrimers are encompassed within this technology.

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Shuo, https://stock.adobe.com/257639945

ADVANTAGES:

• Zwitterionic dendrimers possess an outer layer of zwitterionic characteristics and regioselectivity based on their focal reactive groups.
• Focal reactive groups offer regioselectivity for directing chemical reactions
• Compared to functional PEGs and other zwitterionic polymers, ZDs exhibit:
  • Higher peripheral hydrophilicity
  • Lower cellular uptake
  • Lower cytotoxicity
  • Monodisperse
  • Production shows highly reproducible batch-to-batch performance
• Compared to other dendrimers, ZDs exhibit:
  • Higher water solubility
  • Higher peripheral hydrophilicity
  • Regioselective reactivity
  • Reduction of side reactions for well-controlled coordination of reactions
• Synthesis of ZDs allows for structured copolymer formation with defined characteristics

APPLICATIONS:

• Customizable zwitterionic dendrimer products
• Directed copolymer formation
• Regioselective chemical reaction control

INTELLECTUAL PROPERTY SUMMARY:

US Provisional Patent Application 63/934,581 filed December 9, 2025.

STAGE OF DEVELOPMENT

Laboratory demonstration through in vitro and in vivo experiments.

LICENSING STATUS:

Available for licensing or collaboration.

RELEVANT PUBLICATIONS:

Synthesis, Characterization, and In Vitro Properties of Zwitterionic Dendrimers with a Reactive Focal Functionality for Biomedical Applications | Langmuir