Brief Description: The invention provides a method for combating biofilm, said method comprising contacting a surface at-risk for biofilm formation or a biofilm with a composition comprising an effective amount of antimicrobial peptide biofilm-degrading enzyme combinations, preferably in the form of a fusion protein. The biofilm may be on an animate or inanimate surface and both medical and non-medical uses and methods are provided. In one aspect the invention provides a composition for use in the treatment or prevention of a biofilm infection in a subject, particularly in the oral cavity. Image: Caption: Reference Media Title: Reference Media: Intellectual Property Title: Intellectual Property: Intellectual Property: US2022-0249627A1 Docket Number: Docket#: 22-9964