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Precision cellular imaging for advanced biological analysis
A novel DNA-based imaging technique enabling visualization of 3D cellular components with super-resolution. Background Super-resolution microscopy has revolutionized biological research by providing finer details beyond the diffraction limit of conventional microscopy. A particular challenge in this field is the visualization of small and dynamic...
Published: 3/4/2025   |   Inventor(s): Yi Lu, Quanbing Mou
Keywords(s):  
Category(s): Life sciences > Imaging, Life sciences > Research tools > Tool/assay/screening platform
DNAzyme sensor for selective manganese ion detection in biological systems
A selective DNAzyme-based fluorescent sensor detects manganese ions in cells by lighting up when Mn²⁺ binds, allowing precise monitoring of manganese levels for biological research and potential therapies. Background Manganese (Mn²⁺) is an essential trace element integral to numerous biological processes, acting as a vital cofactor for enzymes...
Published: 1/31/2025   |   Inventor(s): Yi Lu, Zhenglin Yang, Huanhuan Fan
Keywords(s):  
Category(s): Life sciences > Biomaterials
DNAzyme fluorescent sensors for bioselective imaging of Fe²⁺ and Fe³⁺ ions
Developed DNAzyme-based fluorescent sensors that specifically detect and image Fe2⁺ and Fe3⁺ ions in living cells, enabling the study of iron dynamics in biological processes and diseases like Alzheimer’s. Background Iron ions, specifically Fe2⁺ and Fe3⁺, are essential for numerous biological processes, including oxygen transport, DNA synthesis,...
Published: 1/31/2025   |   Inventor(s): Yi Lu, Seyed-Fakhreddin Torabi, Yuting Wu, Ryan Lake, Zhenglin Yang, Peiwen Wu, Whitney Lewis, Jacqueline Van Stappen, Xiangli Shao
Keywords(s):  
Category(s): Life sciences > Biomaterials
DNA aptamer technology for Coenzyme A detection and cellular imaging
Researchers developed a DNA aptamer that specifically targets Coenzyme A, enabling easy and accurate detection in cells. This technology is more specific and simpler than current methods, supporting diagnostics, research, and treatments for diseases involving CoA imbalance. Background The field of biochemical research and medical diagnostics increasingly...
Published: 1/14/2025   |   Inventor(s): Yi Lu, Whitney Lewis, Yuan Ma
Keywords(s):  
Category(s): Life sciences > Therapeutics > Drug screening, Life sciences > Research tools > Tool/assay/screening platform
HIGH OUTPUT, FLEXIBLE PIEZOELECTRIC DEVICES
Princeton Docket # 10-2585 Researchers at Princeton have developed a new design for highly flexible, high output piezoelectric assemblies. Princeton is seeking an industrial partner to commercialize this technology. Current and past devices have relied on low output piezoelectric compounds and mechanical...
Published: 4/10/2025   |   Inventor(s): Michael McAlpine, Yi Qi
Keywords(s):  
Category(s): Mechanical/Electrical Engineering
Non-Invasive, Early-Stage Liver Fibrosis Diagnostic
Description This technology is a cutting-edge non-invasive liver fibrosis detection technology, a revolutionary advancement in the early diagnosis of liver fibrosis. Detecting liver fibrosis early is crucial because it helps address and potentially prevent the progression of liver diseases that can lead to more severe conditions such as cirrhosis,...
Published: 3/12/2025   |   Inventor(s): Yi Jiang, Hao Chen, Sergey Klimov, Bin Zhang
Keywords(s): Liver Disease Detection
Category(s): Diagnostic, Imaging
Kinematic data analysis for stress detection
This technology uses movement data from laparoscopic instruments to detect stress levels in surgeons in near real-time. An AI model analyzes the data, identifying movement patterns associated with stress, and can be integrated into robotic surgical platforms for feedback and guidance. Background Laparoscopic surgery is a complex and demanding field...
Published: 10/23/2024   |   Inventor(s): Ann Majewicz Fey, Yi Zheng
Keywords(s):  
Category(s): Life sciences > Diagnostic, Life sciences > Medical technology > TechBio (software innovation in healthcare)
Attributing Image Generative Models Using Latent Fingerprints
Background Artificial intelligence (AI) image generation has opened up endless possibilities for creativity, allowing architects, designers, and artists to produce visual models rapidly. However, this technology is responsible for creating deepfakes, which are highly realistic but fake images and videos. Deepfakes can be used to spread misinformation,...
Published: 2/13/2025   |   Inventor(s): Guangyu Nie, Changhoon Kim, Yezhou Yang, Yi Ren
Keywords(s):  
Category(s): Physical Science, Wireless & Networking, Intelligence & Security, Artificial Intelligence/Machine Learning
ARPLA: a revolutionary glycoRNA imaging tool with precision and power
Background/problem Glycosylated RNAs (GlycoRNAs) are a newly discovered class of molecules involved in glycosylation. They have been found on the surfaces of various cell types, organisms, and species, further advancing the role of RNA in biological processes. Despite this, our knowledge of glycoRNAs and their functions remains limited, primarily...
Published: 7/26/2024   |   Inventor(s): Yi Lu, Yuan Ma, Weijie Guo, Quanbing Mou
Keywords(s):  
Category(s): Life sciences > Research tools > Tool/assay/screening platform
Fire-retardant and Spectrally Robust Melamine Formaldehyde Photonic Bulk for Efficient Daytime Radiative Cooling
INV-21082 Background: Advances in cooling technologies are essential due to rising global energy consumption driven by the need for comfortable indoor environments. Sub-ambient passive daytime radiative cooling offers a promising solution by radiating heat into space while reflecting most sunlight. However, current materials like porous polymer films...
Published: 9/10/2024   |   Inventor(s): Yi Zheng, Yanpei Tian, Xiaojie Liu
Keywords(s): fire retardant, passive radiative cooling, photonic bulk, spectrally robust
Category(s): Technology Classifications > 2. Physical Science
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