Search Results - thyroid

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Humanized Mouse Model to Study Mesothelin (MSLN) -targeted Cancer Therapeutics: Bl6/TPO Mice
Abstract: Mesothelin (MSLN) is an antigen highly expressed in several human cancers including mesotheliomas, ovarian cancers and pancreatic cancers. As such, human MSLN (hMSLN) is a target for many anti-cancer drugs. Most therapeutics targeting hMSLN do not recognize the mouse isoform of MSLN (mMSLN) and therefore cannot be tested in mouse cancer models.  Investigators...
Published: 5/14/2025   |   Inventor(s): Christine Alewine, Serguei Kozlov, Xianyu Zhang, Theresa Guerin, Theresa O'Sullivan, Norman Collins, Jerome Schlomer
Keywords(s): Alewine, Bl6/TPO, Cancer Animal Model, hMSLN, Humanized Mice, MESOTHELIN, MSLN, Murine Model, THYROID
Category(s): Collaboration Sought > Licensing, Application > Research Materials, TherapeuticArea > Oncology
Stratifying the risk of malignancy in indeterminate thyroid nodules
Project ID D2019-45 Background Thyroid cancer is the most common endocrine cancer globally, and accounts for 3.4% of all new cancer cases in the US. Although several clinical guidelines to detect/manage thyroid nodules are available, a great deal of controversy still exists around the optimal approach for diagnosis. Approximately 20-30% of cytology...
Published: 3/7/2025   |   Inventor(s): Shahnawaz Imam, Juan Jaume
Keywords(s): Atypia of undetermined significance (AUS), Euthyroid Hashimoto thyroiditis (EHT), Fine needle aspiration (FNA), Follicular lesion of undetermined significance (FLUS), Thyroid, Thyroid cancer diagnostic/prognostic markers
Category(s): Diagnostics, Oncology