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Search Results - thyroid
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GTF2I Mutations as a Genetic Marker for Prognosis of Thymic Malignancies
Abstract: Thymoma and thymic carcinomas are a rare and poorly understood group of malignancies. Despite the growing number of biomarkers that are used for diagnosing and treating carcinomas in general, cancers of the thymus are still diagnosed, stratified and treated by a costly combination of histology, surgery and radiological procedures. The lack...
Published: 4/8/2024
|
Inventor(s):
Giuseppe Giaccone
,
Yisong Wang
Keywords(s):
THYMIC
,
thymoma
,
THYROID
Category(s):
Collaboration Sought > Licensing
,
TherapeuticArea > Oncology
,
Application > Diagnostics
Humanized Mouse Model to Study Mesothelin (MSLN) -targeted Cancer Therapeutics: Bl6/TPO Mice
Abstract: Mesothelin (MSLN) is an antigen highly expressed in several human cancers including mesotheliomas, ovarian cancers and pancreatic cancers. As such, human MSLN (hMSLN) is a target for many anti-cancer drugs. Most therapeutics targeting hMSLN do not recognize the mouse isoform of MSLN (mMSLN) and therefore cannot be tested in mouse cancer models. Investigators...
Published: 5/21/2024
|
Inventor(s):
Christine Alewine
,
Serguei Kozlov
,
Xianyu Zhang
,
Theresa Guerin
,
Theresa O'Sullivan
,
Norman Collins
,
Jerome Schlomer
Keywords(s):
Alewine
,
Bl6/TPO
,
Cancer Animal Model
,
hMSLN
,
Humanized Mice
,
MESOTHELIN
,
MSLN
,
Murine Model
,
THYROID
Category(s):
Collaboration Sought > Licensing
,
Application > Research Materials
,
TherapeuticArea > Oncology
Stratifying the risk of malignancy in indeterminate
thyroid
nodules
Project ID D2019-45 Background
Thyroid
cancer is the most common endocrine cancer globally, and accounts for 3.4% of all new cancer cases in the US. Although several clinical guidelines to detect/manage thyroid nodules are available, a great deal of controversy still exists around the optimal approach for diagnosis. Approximately 20-30% of cytology...
Published: 6/18/2024
|
Inventor(s):
Shahnawaz Imam
,
Juan Jaume
Keywords(s):
Atypia of undetermined significance (AUS)
,
Eu
thyroid
Hashimoto thyroiditis (EHT)
,
Fine needle aspiration (FNA)
,
Follicular lesion of undetermined significance (FLUS)
,
Thyroid
,
Thyroid
cancer diagnostic/prognostic markers
Category(s):
Diagnostics
,
Oncology