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Search Results - thyroid
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Humanized Mouse Model to Study Mesothelin (MSLN) -targeted Cancer Therapeutics: Bl6/TPO Mice
Abstract: Mesothelin (MSLN) is an antigen highly expressed in several human cancers including mesotheliomas, ovarian cancers and pancreatic cancers. As such, human MSLN (hMSLN) is a target for many anti-cancer drugs. Most therapeutics targeting hMSLN do not recognize the mouse isoform of MSLN (mMSLN) and therefore cannot be tested in mouse cancer models. Investigators...
Published: 5/14/2025
|
Inventor(s):
Christine Alewine
,
Serguei Kozlov
,
Xianyu Zhang
,
Theresa Guerin
,
Theresa O'Sullivan
,
Norman Collins
,
Jerome Schlomer
Keywords(s):
Alewine
,
Bl6/TPO
,
Cancer Animal Model
,
hMSLN
,
Humanized Mice
,
MESOTHELIN
,
MSLN
,
Murine Model
,
THYROID
Category(s):
Collaboration Sought > Licensing
,
Application > Research Materials
,
TherapeuticArea > Oncology
Stratifying the risk of malignancy in indeterminate
thyroid
nodules
Project ID D2019-45 Background
Thyroid
cancer is the most common endocrine cancer globally, and accounts for 3.4% of all new cancer cases in the US. Although several clinical guidelines to detect/manage thyroid nodules are available, a great deal of controversy still exists around the optimal approach for diagnosis. Approximately 20-30% of cytology...
Published: 3/7/2025
|
Inventor(s):
Shahnawaz Imam
,
Juan Jaume
Keywords(s):
Atypia of undetermined significance (AUS)
,
Eu
thyroid
Hashimoto thyroiditis (EHT)
,
Fine needle aspiration (FNA)
,
Follicular lesion of undetermined significance (FLUS)
,
Thyroid
,
Thyroid
cancer diagnostic/prognostic markers
Category(s):
Diagnostics
,
Oncology