Search Results - therapeutics+%3e+metabolism+and+endocrinology

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Novel Biomarkers for Sanfilippo Syndrome (UCLA Case No. 2024-150)
UCLA researchers from the Department of Neurology have identified novel biomarkers of Sanfilippo Syndrome, leading to potential minimally invasive methods to detect Sanfilippo Syndrome and assess clinical trial outcomes. More information to follow. Contact UCLA Technology Development Group if you would like to learn more in the meantime.
Published: 6/3/2026   |   Updated: 6/3/2026   |   Inventor(s): Gal Bitan
Keywords(s):  
Category(s): Therapeutics > CNS and Neurology, Therapeutics > Metabolism And Endocrinology, Diagnostic Markers > Targets And Assays
Compounds and Methods for Inducing UCP1 Expression (UCLA Case No. 2019-272)
UCLA researchers in the Department Human Genetics have identified small molecules that induce UCP1 expression and thermogenic mitochondrial activity in adipocytes, providing a novel class of potential therapeutics for obesity and related conditions. BACKGROUND: Obesity affects more than 93 million Americans and continues to rise in prevalence. Modulating...
Published: 4/14/2026   |   Updated: 3/26/2026   |   Inventor(s): Laurent Vergnes, Karen Reue
Keywords(s):  
Category(s): Therapeutics > Metabolism And Endocrinology, Therapeutics > Cardiovascular, Life Science Research Tools > Other Reagents
Indole-3-Propionic Acid (IPA) Protects Against Heart Failure with Preserved Ejection Fraction (HFpEF) (UCLA Case No. 2022-142)
UCLA researchers in the Department of Medicine, Division of Cardiology have identified the protective effects of gut-heart crosstalk mediated by 3-propionic acid (IPA) in the progression of heart failure with preserved ejection fraction (HFpEF). IPA supplementation could rescue the IPA deficiency associated heart defects, protect against heart malfunction,...
Published: 2/26/2026   |   Updated: 2/5/2026   |   Inventor(s): Aldons Lusis, Yang Cao
Keywords(s):  
Category(s): Therapeutics > Cardiovascular, Therapeutics > Inflammation And Inflammatory Diseases, Therapeutics > Metabolism And Endocrinology
Coagulation Factor XI (FXI) Functional Roles and Regulation for Treatment of Heart Failure (UCLA Case No. 2022-141)
UCLA researchers from the Department of Medicine have discovered a novel therapeutic target to treat heart failure with preserved ejection fraction (HFpEF), which afflicts approximately half of all patients with heart failure. BACKGROUND: Heart failure is one of the leading causes of death and disease with over 500,000 cases diagnosed each year in...
Published: 2/26/2026   |   Updated: 2/5/2026   |   Inventor(s): Aldons Lusis, Yang Cao
Keywords(s):  
Category(s): Therapeutics > Cardiovascular, Therapeutics > Metabolism And Endocrinology
Combination of Insulin-like Growth Factor-1 Receptor (IGF1R) or Insulin Receptor Inhibitors with Immune Checkpoint Inhibitors in Management of Triple-Negative Breast Cancer (UCLA Case No. 2020-872)
UCLA researchers in the Department Joe C. Wen School of Nursing have developed a novel targeted therapy for triple-negative breast cancer with a potential synergy with immunotherapy. BACKGROUND: Triple-negative breast cancer (TNBC) accounts for about 10-15% of women with breast cancer (BC), but its mortality rate is disproportionally high, causing...
Published: 3/2/2026   |   Updated: 10/6/2025   |   Inventor(s): Nalo Hamilton
Keywords(s):  
Category(s): Therapeutics > Oncology, Therapeutics > Oncology > Oncology Immunotherapy, Therapeutics > Metabolism And Endocrinology, Diagnostic Markers > Cancer, Therapeutics > Women's Health
A Glucose-Responsive Glucagon-Micelle for the Prevention of Hypoglycemia (UCLA Case No. 2024-161)
UCLA researchers in the Department of Chemistry and Biochemistry have developed a novel glucose-responsive drug delivery system that enables the controlled release of glucagon for the prevention of hypoglycemia. BACKGROUND: Diabetes is a metabolic disorder in which the body cannot properly regulate blood sugar levels due to the loss of insulin-producing...
Published: 5/11/2026   |   Updated: 10/2/2025   |   Inventor(s): Heather Maynard, Daniele Vinciguerra, Andrea Hevener, Jane Yang, Rajalakshmi Pallathery Sivasankaran, Panagiotis Georgiou, Katherine Snell, Kathryn Messina
Keywords(s):  
Category(s): Platforms > Drug Delivery, Therapeutics > Metabolism And Endocrinology, Therapeutics > Autoimmune, Chemical > Chemical Sensors, Chemical > Polymers, Materials > Nanotechnology
A Microbial Metabolite That Promotes Stress/Anxiety (UCLA Case No. 2026-007)
UCLA researchers in the Department of Integrative Biology and Physiology have identified microbiota-derived imidazole propionate (ImP) as a key neuromodulatory signal that can be targeted to treat stress-related behaviors and metabolic dysfunction. BACKGROUND: The microbiota-gut-brain axis is a complex network that coordinates metabolic homeostasis....
Published: 5/22/2026   |   Updated: 9/19/2025   |   Inventor(s): Elaine Hsiao, Gulistan Agirman
Keywords(s):  
Category(s): Therapeutics > Metabolism And Endocrinology, Diagnostic Markers > Targets And Assays, Therapeutics > Inflammation And Inflammatory Diseases, Therapeutics > CNS and Neurology
Targeting Metabolic and Molecular Drivers to Stop Treatment- and Immune-Resistant Pancreatic Ductal Adenocarcinoma (UCLA Case No. 2025-9AD)
UCLA researchers in the Department of Medicine–Hematology/Oncology have developed next-generation metformin analogs that show improved antitumor efficacy and tumor microenvironment remodeling in pancreatic cancer. BACKGROUND: Pancreatic ductal adenocarcinoma (PDAC) is the 3rd leading cause of cancer-related death in the U.S. with a 5-year survival...
Published: 5/28/2026   |   Updated: 9/19/2025   |   Inventor(s): Richard Pietras, Michael Jung, Timothy Donahue, Diana Marquez-Garban
Keywords(s):  
Category(s): Therapeutics > Oncology, Therapeutics > Metabolism And Endocrinology, Therapeutics > Inflammation And Inflammatory Diseases
Food Derived Compounds for Improving Cognitive Health (UCLA Case No. 2025-279)
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Published: 6/11/2026   |   Updated: 9/18/2025   |   Inventor(s): Arpana Church, Jennifer Labus
Keywords(s):  
Category(s): Therapeutics > Metabolism And Endocrinology, Therapeutics > Gastroenterology
Glucagon Conjugated Trehalose Diblock Copolymers and Methods of Use (UCLA Case No. 2024-283)
UCLA researchers from the Department of Medicine-Endocrinology have formulated a novel nanoparticle for management of hypoglycemia that can efficiently deliver glucagon, while also allowing for long-term stabilization and storage. BACKGROUND: Hypoglycemia is a condition characterized by abnormally low blood glucose levels, posing a significant risk...
Published: 12/9/2025   |   Updated: 9/16/2025   |   Inventor(s): Heather Maynard
Keywords(s):  
Category(s): Platforms > Drug Delivery, Chemical > Polymers, Therapeutics > Metabolism And Endocrinology
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