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Polymer Materials with Pendent or Chain-End Groups for Catalyst-Free, Low-Temperature Depolymerization
Incorporates Thermolytically Labile Groups to Induce On-Demand Degradation Into Reusable Monomers These materials incorporate thermolytically labile groups into widely used glass-substitute polymers, allowing solvent and catalyst-free degradation of the polymer into a high-purity composition of its monomers. These materials can therefore be recycled...
Published: 7/23/2024   |   Inventor(s): Brent Sumerlin, Megan Lott, James Young, Jared Bowman, Kaden Stevens, Kevin Stewart, Rhys Hughes
Keywords(s):  
Category(s): Technology Classifications > Engineering > Chemical, Technology Classifications > Engineering > Materials
Nitro-Driven Chemical Pathway for Producing Polyfunctionalized Aromatic Compounds
Develops Biaryl Compounds with Stable Axial Chirality This pathway for aromatic substitution provides a straightforward route to polyfunctionalized biaryl compounds with stable axial chirality. The rapid and controlled linking of functional groups and aromatic building blocks is a prominent pattern in developing new pharmaceuticals. In one common aromatic...
Published: 6/24/2024   |   Inventor(s): Alexander Grenning, Vincent Vedovato
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Category(s): Technology Classifications > Engineering > Chemical, Technology Classifications > Agricultural > Therapeutics
Cholesterol Template for Synthesizing Non-Polar Chiral Nanoparticles
Yields Colloidal Chiral Nanoparticles with Consistent Size and Useful Optical Properties This cholesterol ligand template enables the preparation of nonpolar inorganic chiral nanoparticles. Chirality is a fundamental geometrical property with various objects in our universe, enabling matter to adopt three-dimensional arrangements. Chiral molecules...
Published: 9/4/2024   |   Inventor(s): Yunwei Cao, Tianyuan Xiao
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Category(s): Technology Classifications > Engineering > Chemical, Technology Classifications > Engineering > Materials
Cryogenic Propellant Storage Tank Chill-Down and Filling for Refueling in Microgravity and Reduced Gravity Environments
Uses Spray Cooling with Flow Pulsing to Prevent the Unnecessary Boiling of Cryogenic Propellant Film in Microgravity and Reduced Gravity Environments This storage tank and propellant transfer apparatus conserves valuable cryogenic propellants in reduced gravity and microgravity environments. The extension of human space exploration is NASA’s...
Published: 9/3/2024   |   Inventor(s): Jacob Chung, Jason Hartwig, Hao Wang, Bo-Han Huang, Jun Dong
Keywords(s):  
Category(s): Technology Classifications > Engineering > Mechanical, Technology Classifications > Engineering > Chemical
Atheliapyrrolidine A, a Serotonin Receptor Antagonist for Treating Psychotic Disorders
Produces 5-HT2A Receptor Antagonism in a Subject, Enabling the Development of Potential Antipsychotic and/or Antischizophrenic Treatments This compound, Atheliapyrrolidine A, produces 5-HT2A receptor antagonism for treating psychiatric disorders. The 5-HT2A receptor (5-HT2AR) is one of 14 genetically encoded 5-HT serotonin receptors in humans. Antagonists...
Published: 9/3/2024   |   Inventor(s): Sandra Loesgen, Annika Jagels
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Category(s): Technology Classifications > Human Health Care > Therapeutics, Technology Classifications > Engineering > Chemical
Heat Transfer Enhancement System for Removing Heat in Microgravity
Dissipates Heat Using Parametric Electrostatic Forcing This heat transfer system removes heat in zero gravity through conductance using vibrations induced by an AC electrostatic force. Heat transfer in microgravity is limited in the absence of buoyancy-driven convection. The conventional heat transfer approaches on Earth utilize buoyancy-driven flow...
Published: 1/22/2024   |   Inventor(s): Ranganathan Narayanan, William O'Brien, Jason Livesay
Keywords(s):  
Category(s): Technology Classifications > Engineering > Chemical, Technology Classifications > Engineering > Mechanical
Catalyst for the Synthesis of Cyclic Polyalkynes
Enhances the Rate of Reactions of Various Energy Substrates This catalyst has the ability to transform cyclic alkynes into cyclic polyalkynes, which have different functional properties than the linear polymer. Catalysts are important in creating compounds for the energy industry such as motor oil, biofuels, and flexible electronics. The escalating...
Published: 11/16/2023   |   Inventor(s): Adam Veige, Andrew Beauchamp
Keywords(s):  
Category(s): Technology Classifications > Engineering > Chemical, Technology Classifications > Engineering > Materials
Broad-Spectrum Nanozymes for the Treatment of Cancer and Viral Infections
Effectively Degrade RNA in a Non-Sequence Specific Manner and in the Presence of RNase Inhibitors Hollow broad-spectrum nanozymes can degrade intracellular RNA in the presence of ribonuclease inhibitors (RIs) in a non-sequence-specific fashion. RNA translates genetic information into proteins constituting cell structures and crucial molecular regulators,...
Published: 11/16/2023   |   Inventor(s): Yunwei Cao, Tian Jiang
Keywords(s):  
Category(s): Technology Classifications > Engineering > Chemical, Technology Classifications > Human Health Care > Therapeutics
Ultrasonic Spray Injection Reactor for Rapid Preparation of Hyperpolarized Metabolites
Efficiently Generates Hyperpolarized Metabolites Used as Biomarkers in Disease Detection and Monitoring in Magnetic Resonance Imaging This system uses an ultrasonic spray injection hydrogenation reactor to rapidly prepare hyperpolarized metabolites for sensitivity-enhanced nuclear magnetic resonance spectroscopy and magnetic resonance imaging. Using...
Published: 7/24/2023   |   Inventor(s): Clifford Bowers, Maria-Jose Ferrer
Keywords(s):  
Category(s): Technology Classifications > Engineering > Chemical, Technology Classifications > Engineering > Mechanical
PEGylation of the Human Galectin-3C Protein for Improving Biologic Therapeutic Use
Increases the Stability and Robustness of the Galectin-3C Protein PEGylation of the carbohydrate recognition domain of human Galectin-3 (Gal3C) increases the stability and robustness of the protein, overcoming limitations hindering its biologic therapeutic use. Biologics are highly effective, targeted treatments for varying diseases, constituting approximately...
Published: 8/21/2023   |   Inventor(s): Matthew Eddy, Michael Harris, Amanda Pritzlaff
Keywords(s):  
Category(s): Technology Classifications > Engineering > Chemical, Technology Classifications > Human Health Care > Therapeutics
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