Search Results - tamir+gonen

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Cohesive CLEM, TEM, FEBSEM System for MicroED and Cryo-EM Applications (Case No. 2025-010)
Summary UCLA researchers have developed a cohesive electron microscope system that uniquely integrates transmission electron microscopy (TEM), fluorescence microscopy, and focused ion beam scanning electron microscopy (FIB-SEM) into a single automated column. The platform supports both cryogenic and room-temperature workflows, enabling fully automated...
Published: 9/12/2025   |   Inventor(s): Tamir Gonen, Michael Martynowycz
Keywords(s):  
Category(s): Life Science Research Tools, Life Science Research Tools > Microscopy And Imaging, Life Science Research Tools > Research Methods, Medical Devices, Medical Devices > Medical Imaging, Platforms
Methods for Automation and Compositional Analyses of MicroED Data (Case No. 2023-256)
Summary UCLA researchers have developed an automated Microcrystal Electron Diffraction (MicroED) microscopy system and method that autonomously identifies, images, and analyzes micro-crystals on an EM grid. The system captures low-magnification atlases, selects promising grid squares, acquires higher-magnification montages, sets focus, captures continuous-rotation...
Published: 9/11/2025   |   Inventor(s): Tamir Gonen, Johan Unge
Keywords(s):  
Category(s): Life Science Research Tools, Life Science Research Tools > Research Methods
On Grid Sample Growth Device for Imaging Applications (Case No. 2023-048)
Summary UCLA researchers have developed a suspended drop crystallization device and associated methods that allow a sample to be applied directly onto a support-free electron microscopy grid and then incubated in a chamber (“incubation pod”) that permits vapor diffusion from both sides. The device has viewing windows for monitoring crystal...
Published: 9/11/2025   |   Inventor(s): Tamir Gonen, Cody Gillman
Keywords(s):  
Category(s): Medical Devices, Medical Devices > Medical Imaging, Life Science Research Tools, Life Science Research Tools > Microscopy And Imaging
2020-883 A METHOD FOR HIGH THROUGHPUT DRUG DISCOVERY USING MICROED
SUMMARY Researchers in the UCLA Department of physiology have invented a new drug discovery system based on high throughput screening.BACKGROUNDAtomic resolution structures are critical to understanding how proteins and small molecule function, therefore being an important step in the drug discovery, development and delivery process. Traditionally,...
Published: 7/17/2025   |   Inventor(s): Tamir Gonen
Keywords(s):  
Category(s): Life Science Research Tools, Life Science Research Tools > Microscopy And Imaging, Life Science Research Tools > Research Methods, Medical Devices > Medical Imaging
2020-432 Outrunning Radiation Damage by Collecting Rapid Low-Dose Microed Datasets Using a Direct Electron Detector
Summary: UCLA researchers in the Department of Biological Chemistry and Physiology have developed a novel method to collect MicroED datasets using a direct electron detector. Background: Microcrystal electron diffraction (MicroED) is a method in electron cryo-microscopy (cryo-EM) that exploits the strong interaction of electrons with matter to determine...
Published: 7/17/2025   |   Inventor(s): Tamir Gonen, Michael Martynowycz, Johan Hattne
Keywords(s): Life Science Research Tools, Microscopy And Imaging
Category(s): Life Science Research Tools > Microscopy And Imaging, Life Science Research Tools > Research Methods
2018-167 A NEW APPROACH TO HIGH THROUGHPUT DRUG DISCOVERY IN GPCRS USING MICROED
INTRODUCTION:UCLA researchers in the Department of Physiology have proposed a new and powerful method for unbiased structure based high throughput drug discovery for G-protein coupled receptors (GPCRs) using microcrystal electron diffraction (MicroED). BACKGROUND:X-ray crystallography is one of the techniques for determining protein structures at atomic...
Published: 2/14/2025   |   Inventor(s): Tamir Gonen
Keywords(s): Life Science Research Tools, Research Methods, Targets And Assays
Category(s): Life Science Research Tools > Research Methods