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A Method to Isolate Tumor Specific T-Cells or T-Cell Receptors from Peripheral Blood using In-vitro Stimulation of Memory T-Cells
Abstract: Adoptive cell transfer (ACT) and T-cell receptor (TCR) therapies use lymphocytes that target somatic mutations expressed by tumors cells to treat cancer patients. One of the challenges of these therapies is the identification and isolation of mutation-specific cells and TCRs. While neoantigen specific cells are relatively abundant in the tumor,...
Published: 4/8/2024   |   Inventor(s): Gal Cafri, Steven Rosenberg
Keywords(s): act, Adoptive Cell Transfer therapy, Immunotherapy, In-vitro Stimulation, IVS, Rosenberg, T-cell Isolation, T-Cell Receptor, TCR
Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Application > Therapeutics, TherapeuticArea > Oncology