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Search Results - rosanne+spolski
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Treatment of Viral Infection by Blocking Interleukin-21
Blocking interleukin (IL-21) may be an effective method to treat or prevent various viral infections. In the course of an immune response to a virus, IL-21, produced primarily by CD4+ T cells, can inhibit or stimulate (regulate), immune cell function (B cells, T cells, natural killer cells, dendritic cells). IL-21 regulation may be either protective...
Published: 4/8/2024
|
Inventor(s):
Rosanne Spolski
,
Warren Leonard
Keywords(s):
Blocking
,
DBXXXX
,
DISCOVERING
,
DXXXXX
,
IL-21
,
INCREASES
,
Model
,
PNEUMONIA
,
SURVIVAL
,
That
,
viral
Category(s):
Collaboration Sought > Collaboration
,
Application > Therapeutics
,
TherapeuticArea > Infectious Disease
IL-21 Critically Regulates Immunoglobulin Production
The invention includes a mouse in which the IL-21 receptor gene is disrupted by homologous recombination, the disruption being sufficient to prevent expression of the IL-21 receptor and thus to inhibit the action of IL-21. The invention also includes a mouse in which both the IL-21 receptor gene and the IL-4 gene are simultaneously disrupted in fashions...
Published: 10/28/2024
|
Inventor(s):
Warren Leonard
,
Katsutoshi Ozaki
,
Rosanne Spolski
Keywords(s):
IBXXXX
,
IDXXXX
,
IXXXXX
Category(s):
Collaboration Sought > Licensing
,
Application > Diagnostics
,
Application > Research Materials
,
Application > Therapeutics