Search Results - roderic+eckenhoff

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EGFRvIII Antibodies for the Treatment of Human Cancer
Abstract: Epidermal growth factor receptor variant III (EGFRvIII) is a variant of EGFR that is an excellent target for immunotherapy because of its expression in cancer cells and not in normal cells.  Inventors from the National Cancer Institute (NCI) have isolated seven mouse monoclonal antibodies that bind to the human EGFRvIII but not wildtype EGFR....
Published: 4/8/2024   |   Inventor(s): David Fitzgerald, Antonella Antignani, Eric Ho, Robert Sarnovsky
Keywords(s): ADC, Antibody-drug Conjugate, CAR, chimeric antigen receptor, EGFR, EGFRvIII, Epidermal Growth Factor Receptor, Epidermal growth factor receptor variant III, FitzGerald, Recombinant Immunotoxins, RITs
Category(s): Application > Therapeutics, TherapeuticArea > Oncology, Collaboration Sought > Collaboration, Collaboration Sought > Licensing
Library of Novel Anesthetic (Propofol) Antagonists
A library of chemical compounds that reverse the anesthetic effects of propofol. Problem: Propofol is one of the most commonly used anesthetics in medical care. It is used to induce and maintain sedation in surgeries, ICU care, emergency care, and other procedures. However, there currently is no pharmacological method for reversing propofol-induced...
Published: 2/2/2024   |   Inventor(s): Elizabeth White, Roderic Eckenhoff, William Dailey, Kellie Woll, Andrew McKinstry-Wu, Victoria Bedell
Keywords(s): Drug Target, Surgery
Category(s): Technology Classifications > Chemical Processes and Synthesis