Search Results - robert+wilson

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Novel Inhibitors of Ferroptosis
Novel derivatives of oleic acid effectively inhibiting ferroptosis that could be used for treatment of Friedreich Ataxia, neurodegenerative diseases, and neuropsychiatric diseases. Problem: Ferroptosis is a non-apoptotic form of cell death characterized by the iron-dependent accumulation of toxic lipid-reactive oxygen species. Ferroptosis has been...
Published: 3/13/2024   |   Inventor(s): Robert Wilson, Maria Cotticelli, Shujuan Xia, Donna Huryn, Amos Smith, Taehee Lee, Roberto Forestieri
Keywords(s): Neurodegenerative Diseases
Category(s): Technology Classifications > Therapeutics
Drug Discovery and Target Identification Platform Technology Using Random shRNA-Expressing Library
shRNA library of 3 million sequences for identification of small-RNA therapeutic candidates, new targets and pathways, as well as conventional chemical-compound drugs in cell-culture disease models. Problem: ShRNA Drug Discovery: RNA interference (RNAi) using short hairpin RNA (shRNA) is commonly used to inhibit gene expression. shRNA-expressing...
Published: 6/18/2024   |   Inventor(s): Robert Wilson
Keywords(s): Neurodegenerative Diseases
Category(s): Technology Classifications > Diagnostics, Technology Classifications > Research Tools & Reagents, Technology Classifications > Therapeutics
Use of MAPK Pathway Inhibitors for the Treatment of Friedreich Ataxia
A novel treatment for rare disease Friedreich ataxia using p38 or MK2 kinase inhibitors Technology Overview: Friedreich ataxia (FA) is an autosomal recessive, inherited neuro- and cardio-degenerative disorder characterized by progressive ataxia of all four limbs, skeletal deformities, and hypertrophic cardiomyopathy. FA is the most prevalent inherited...
Published: 6/21/2024   |   Inventor(s): Robert Wilson
Keywords(s): Orphan Disease
Category(s): Technology Classifications > Therapeutics