Search Results - relaxin

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Novel Small Molecule Agonists of the Relaxin Receptor as Potential Therapy for Heart Failure and Fibrosis
The present invention is directed to novel small molecule agonists of the mammalian relaxin family receptor 1 (RXFP1), including human RXFP1. Activation of RXFP1 induces: 1) vasodilation due to up-regulation of the endothelin system; 2) extracellular matrix remodeling; 3) moderation of inflammation by reducing levels of inflammatory cytokines; and...
Published: 10/28/2024   |   Inventor(s): Wei Zheng, Marc Ferrer-Alegre, Catherine Chen, Alexander Agoulnik, Noel Southall, Jingbo Xiao, Juan Marugan
Keywords(s): 1, IB1XXX, IB3XXX, IB5XXX, IB6XXX, IBXXXX, IXXXXX, MODULATORS, POTENT, RECEPTOR, Relaxin, RXFP1, SELECTIVE
Category(s): Collaboration Sought > Collaboration, Application > Therapeutics, Application > Vaccines, TherapeuticArea > Cardiology, TherapeuticArea > Reproductive Health, TherapeuticArea > Immunology, Application > Research Materials, Application > Diagnostics
Use of Relaxin as a Therapeutic Agent in Preeclampsia and Other Medical Conditions
Increases the Circulating Number and Activity of Bone Marrow-Derived Endothelial Progenitor Cells Without Causing Inflammation, Offering Potential as a Therapeutic in Cardiovascular DiseaseThis use of the hormone relaxin, relaxin-like peptides or mimetics to positively impact the number and function of bone marrow-derived endothelial progenitor cells...
Published: 6/27/2021   |   Inventor(s): Mark Segal, Kirk Conrad
Keywords(s): bone marrow derived endothelial cells, relaxin
Category(s): Technology Classifications > Human Health Care, Technology Classifications > Human Health Care > Therapeutics
Therapeutic Use of Relaxin to Reduce Risk in Pregnancies Aided by Assisted Reproductive Technologies
Improves Maternal Physiology and Cardiovascular Adaptations During Pregnancy This treatment option provides recombinant relaxin to patients conceiving by Assisted Reproductive Technologies (ART), restoring overall cardiovascular conditions during pregnancy. Assisted reproductive technology aims to obtain pregnancy by way of in vitro fertilization of...
Published: 6/27/2021   |   Inventor(s): Kirk Conrad
Keywords(s): Assisted Reproductive Technology, Embryo, infertility, IYF, relaxin, relaxin mimetic
Category(s): Technology Classifications > Human Health Care > Therapeutics