Search Results - nuria+marti-gutierrez

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CRISPR/Cas9-targeted correction of heterozygous mutations in human preimplantation embryos
Technology Overview More than 10,000 monogenic inherited disorders have been identified, affecting millions of people worldwide. Among these are the autosomal dominant mutations, where inheritance of a single copy of a defective gene can result in clinical symptoms. Dominant mutations that manifest as late-onset adult disorders include BRCA1 and BRCA2,...
Published: 9/30/2022   |   Inventor(s): Shoukhrat Mitalipov, Nuria Marti-Gutierrez
Keywords(s): Therapeutics - Reproductive
Category(s): Therapeutics
A method to increase pregnancy rates for treatment of infertility
Summary A method of generating functional human oocytes from polar bodies, which could be utilized to increase viable oocyte retrieval and prevent transmission of inherited mitochondrial DNA mutations. Technology Overview Because of the trend toward delayed childbearing in the Western world, the age-related infertility, embryonic and fetal loss,...
Published: 11/3/2022   |   Inventor(s): Shoukhrat Mitalipov, Nuria Marti-Gutierrez, Dmitry Temiakov
Keywords(s): Biological Materials - Cell Lines, Therapeutics - Reproductive
Category(s): Biological Materials, Therapeutics