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D3-Selective Dopamine Agonist Platform: Eliminating D2-Mediated Side Effects in Parkinson’s and Movement Disorders
Every major dopaminergic therapy on the market today shares the same fundamental limitation: it cannot distinguish between two closely related receptor subtypes (D2 and D3). This technology changes that. We have discovered and optimized a novel small molecule, ML417, that selectively activates the D3 dopamine receptor while leaving its close cousin,...
Published: 8/4/2026
|
Updated: 8/4/2026
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Inventor(s):
David Sibley
,
Juan Marugan
,
Benjamin Free
,
Amy Moritz
,
Jeffrey Aube
,
Joseph Steiner
,
Kevin Frankowski
,
Marc Ferrer-Alegre
,
Noel Southall
,
Xin Xu
,
Warren Weiner
Keywords(s):
Category(s):
TherapeuticArea > Neurology
,
Application > Therapeutics