Search Results - il-15

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Use of Heterodimeric IL-15 in Adoptive Cell Transfer
Abstract: Adoptive cell transfer (ACT) is a promising immunotherapeutic approach for cancer treatment. During ACT, if a patient is subjected to lymphodepletion prior to cell transfer, there is an observed improvement in a patient’s response to treatment. However, lymphodepletion is associated with detrimental effects, including severe immune dysfunction...
Published: 5/22/2024   |   Inventor(s): George Pavlakis, Barbara Felber, Christina Bergamaschi
Keywords(s): act, Adoptive Cell Transfer, HetIL-15, IL-15, Immunotherapy, Interleukin 15, Lymphodepletion, Receptor Alpha Complex
Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Application > Therapeutics, TherapeuticArea > Oncology
Tethered Interleukin-15 (IL-15)/IL-21 to Enhance T Cells for Cellular Therapy
Abstract: Interleukin-15 (IL-15) and IL-21 have been reported to support the function of anti-tumor T cells.  However, their use in the clinic has been constrained, in part, by dose-limiting toxicity and the need for repeated administration.  To overcome these limitations, researchers in the National Cancer Institute (NCI) Experimental Transplantation...
Published: 4/8/2024   |   Inventor(s): Christian Hinrichs, Benjamin Jin
Keywords(s): act, adoptive cell therapy, CANCER, CAR, chimeric antigen receptor, Hinrichs, IL-15, IL-21, INTERLEUKIN-15, Interleukin-21, T Cells
Category(s): TherapeuticArea > Oncology, Application > Therapeutics, Collaboration Sought > Licensing