Search Results - ib1exx

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Stapled Peptides for Treatment of Cardiovascular Diseases and Inflammation
The invention is directed to small molecule mimetics of apolipoproteins that have an inter-helical hydrocarbon bond, which stabilizes helix formation. Apolipoproteins facilitate the transport of lipids and cholesterol in the body. Mimetics of apolipoproteins have been used to treat cholesterol-related disorders. However, these mimetics are susceptible...
Published: 4/8/2024   |   Inventor(s): Marcelo Amar, Imoh Ikpot, Denis Sviridov, David Osei-Hwedieh, Alan Remaley
Keywords(s): Acylation, ALKYLATION, AMPHIPATHIC, Biological, IB1CXX, IB1DXX, IB1EXX, IB1FXX, IB1XXX, IBXXXX, IXXXXX, Peptides, PROPERTIES, Their, therapeutic
Category(s): Collaboration Sought > Collaboration, Application > Therapeutics, Application > Diagnostics, TherapeuticArea > Cardiology, Application > Research Materials
Collagen-Induced Platelet Aggregation Inhibitor from Mosquito Salivary Glands
Exposed collagen in injured blood vessels provides a substrate for platelets to adhere and aggregate initiating the first step in thrombosis, the formation of blood clots inside a blood vessel. Despite the essential role of platelets in vascular injury, excessive platelet aggregation may also result in thrombotic diseases such as stroke and heart attack. Available...
Published: 10/28/2024   |   Inventor(s): Eric Calvo
Keywords(s): AGGREGATION, Collagen-platelet, GLANDS, IB1EXX, IB1XXX, IB3XXX, IBXXXX, inhibitor, IXXXXX, Malaria, Mosquito, Salivary
Category(s): Collaboration Sought > Collaboration, TherapeuticArea > Immunology, Application > Research Materials, Application > Diagnostics, TherapeuticArea > Cardiology, Application > Therapeutics