Search Results - hsin-chih+(tim)+yeh

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Enhanced fluorescence via DNA aptamer optimization
This invention improves the fluorescence of DNA-based aptamers by sub­stituting the original fluorophore with TO1-biotin and identifying a critical mutation that further enhances fluorescence. Background Fluorogenic DNA aptamers (FAPs) are a crucial tool in molecular biology, particularly for applications like live-cell imaging and highly specific...
Published: 12/6/2024   |   Inventor(s): Hsin-Chih (Tim) Yeh, Yuan-I Chen, Yu-An Kuo, Yujie He, Trung Nguyen, Soonwoo Hong, Anh-Thu Nguyen, Sohyun Kim, Saeed Seifi
Keywords(s):  
Category(s): Life sciences > Research tools > Tool/assay/screening platform
Fluorescence lifetime imaging for retinal function assessment
This invention uses a laser-based imaging system to study the eye’s retina. By measuring light responses, it provides insights into retinal health and potential diseases like age-related macular degeneration. Background Two-photon excited fluorescence (TPEF) is a powerful technique used to study the eye. TPEF allows researchers to excite intrinsic...
Published: 10/24/2024   |   Inventor(s): Hsin-Chih (Tim) Yeh, Trung Nguyen, Yuan-I Chen, H. Grady Rylander, Yu-An Kuo, Soonwoo Hong, Anh-Thu Nguyen, Yujie He
Keywords(s):  
Category(s): Life sciences > Imaging, Life sciences > Imaging > Microscopy
High-speed, high-precision, deep-tissue three-dimensional single-particle tracking
The invention enhances particle tracking in biological research using spatio­temporal offset light beams with two-photon microscopy. It achieves high-speed, precise, deep tissue tracking, offering improved penetration depth and temporal resolution for studying molecular processes. Background Single-particle tracking (SPT) is a powerful tool for...
Published: 10/3/2024   |   Inventor(s): Andrew Dunn, Hsin-Chih (Tim) Yeh, Evan Perillo
Keywords(s):  
Category(s): Life sciences > Imaging > Microscopy, Life sciences > Diagnostic
Chameleon NanoCluster Beacons for single N6-adenosine methylation detection
Problem N6-methyladenosine (m6A) is the most prevalent modification found on eukaryotic mRNA. This modification is implicated in the development of cancer, stem cell differentiation, control of circadian rhythm, and more. m6A bases cannot be detected directly by sequencing, because the m6A modification does not change the base pairing properties and...
Published: 12/8/2023   |   Inventor(s): Hsin-Chih (Tim) Yeh, Judy Obliosca, Yu-An Chen, Cong Liu, Yen-Liang Liu
Keywords(s):  
Category(s): Life sciences > Biomaterials, Life sciences > Research tools > Tool/assay/screening platform
­Low-cost fluorescent reporters for nuclease activity detection
Problem DNA cleavage or nuclease activity detection is important in many forms of nucleic acid amplification tests. The current detection technologies rely on the use of fluorescence resonance energy transfer (FRET) reporters that light up upon digestion, such as the Taqman® probe and the DNaseAlert®. Although these FRET reporters well serve...
Published: 6/6/2024   |   Inventor(s): Hsin-Chih (Tim) Yeh, Soonwoo Hong, Yuan-I Chen, Yu-An Kuo, Trung Nguyen, Hsin-Chin Li
Keywords(s):  
Category(s): Life sciences > Research tools > Tool/assay/screening platform, Life sciences > Agriculture > Animal/veterinary
Deep learning for rapid and robust fluorescence lifetime imaging
Deep-learning approach has the potential to unlock fluorescent lifetime imaging for clinical applications. Fluorescence lifetime imaging microscopy (FLIM) is a widely used tool for biomedical imaging that offers many unique advantages over typical intensity-based fluorescence microscopy. FLIM is advancing fundamental biological research by enabling...
Published: 11/1/2023   |   Inventor(s): Hsin-Chih (Tim) Yeh, Yuan-I Chen, Yin-Jui Chang, Shih-Chu Liao, Trung Nguyen, Soonwoo Hong, Yu-An Kuo, Hsin-Chin Li
Keywords(s): Artificial intelligence (AI), Cancer, Diagnostics, Imaging, Machine learning, Medical imaging, Microscopy
Category(s): Life sciences > Imaging > Microscopy, Life sciences > Imaging