Search Results - federico+hoffmann

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mRNA Treatment to Induce Expression of Relaxin for Reproductive Applications in Animals and Humans
Background Female cattle and other animals, including humans, sometimes have trouble delivering their young (dystocia) at the time they are due because of inadequate relaxation or size of the mother's reproductive tract. Such situations can lead to difficult deliveries that may be harmful to the mother or the offspring. They may also require surgery...
Published: 9/9/2024   |   Inventor(s): Peter Ryan, Amelia Woolums, Elmer King, Merrilee Thoresen, Federico Hoffmann
Keywords(s): Human Health, Veterinary Medicine
Category(s): Biotechnology, Veterinary Medicine
EGFRvIII Antibodies for the Treatment of Human Cancer
Abstract: Epidermal growth factor receptor variant III (EGFRvIII) is a variant of EGFR that is an excellent target for immunotherapy because of its expression in cancer cells and not in normal cells.  Inventors from the National Cancer Institute (NCI) have isolated seven mouse monoclonal antibodies that bind to the human EGFRvIII but not wildtype EGFR....
Published: 4/8/2024   |   Inventor(s): David Fitzgerald, Antonella Antignani, Eric Ho, Robert Sarnovsky
Keywords(s): ADC, Antibody-drug Conjugate, CAR, chimeric antigen receptor, EGFR, EGFRvIII, Epidermal Growth Factor Receptor, Epidermal growth factor receptor variant III, FitzGerald, Recombinant Immunotoxins, RITs
Category(s): Application > Therapeutics, TherapeuticArea > Oncology, Collaboration Sought > Collaboration, Collaboration Sought > Licensing