Search Results - eugene+mash%2c+jr.

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Scalable Synthesis for Commercial Production of Carbohydrate-Based Molecular Scaffold Compounds for Direct Delivery of Drugs or Nutritional Supplements to the GI Tract
This invention provides a scalable synthesis method for commercial production (kilogram and greater) of novel carbohydrate-based molecular scaffold compounds for various therapeutic and diagnostic applications that have been and are being developed by UArizona inventors. Oral administration and targeted delivery of pro-drugs or other payloads, such...
Published: 3/12/2024   |   Inventor(s): Eugene Mash, Jr.
Keywords(s):  
Category(s): Technology Classifications > Materials > Processing, Technology Classifications > Healthcare Portfolios > Gastroenterology Disease, Technology Classifications > Life Sciences > Drug Delivery, Technology Classifications > Life Sciences > Nutraceuticals
Design and Synthesis of Pro-Drugs for Selective, Oral Delivery to the Gastrointestinal Tract
This invention provides a method for oral administration and targeted delivery of pro-drugs bonded to a carbohydrate-based molecular scaffold to the gastrointestinal tract, where the pro-drug is released directly in the gastrointestinal (GI) tract by nitroreductase enzymes naturally present. This technology provides a means of delivery of GI therapies...
Published: 3/12/2024   |   Inventor(s): Eugene Mash, Jr., Pawel Kiela
Keywords(s):  
Category(s): Technology Classifications > Life Sciences > Drug Delivery, Technology Classifications > Life Sciences > Therapeutics, Technology Classifications > Life Sciences > Small Molecules, Technology Classifications > Healthcare Portfolios > Oncology, Technology Classifications > Healthcare Portfolios > Gastroenterology Disease
Novel 5-Fluorouracil Prodrug For Colorectal Cancer Therapy
This invention provides a method for a targeted delivery of a commonly used chemotherapy drug, 5-fluorouracil used to treat colorectal cancer. A pro-drug is released within the colon to release the active ingredient. The method will allow for targeted delivery of 5-fluorouracil to the colon. Background: Colorectal cancer is the third most commonly...
Published: 3/12/2024   |   Inventor(s): Eugene Mash, Jr., Pawel Kiela
Keywords(s):  
Category(s): Technology Classifications > Healthcare Portfolios > Oncology
Solvent-Free and Additive-Free Nitration of Arenes
University of Arizona researchers have developed a novel, one-step, catalyst-free, and solvent-free synthetic process for the nitration of aromatic compounds. This method has been used to prepare 2,4-dinitroanisole, an alternative to trinitrotoluene (TNT), as an ingredient in melt-cast explosive formulations; and dinitrophenyl ethers. This synthetic...
Published: 3/12/2024   |   Inventor(s): Eugene Mash, Jr., Bhumasamudram Jagadish
Keywords(s):  
Category(s): Technology Classifications > Materials > Chemicals, Technology Classifications > Life Sciences > Small Molecules
A Streamlined Process to Generate Nitroaromatic Compounds
This invention is a new, one-step, streamlined synthetic process used in the nitration of aromatic compounds. In practice, this novel synthetic method has been used to prepare 2,4-dinitroanisole, a high energy compound with superior resistance to heat and shock. This compound can have uses in the mining and construction industries (roads, bridges, etc.)....
Published: 6/20/2024   |   Inventor(s): Eugene Mash, Jr., Bhumasamudram Jagadish
Keywords(s): Life Sciences, method
Category(s): Technology Classifications > Materials, Technology Classifications > Materials > Chemicals