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Kansuinine A— A Next-Generation HIV Latency-Reversing Agent Targeting ERK/AP-1 Pathway

Despite the success of antiretroviral therapy (ART), latent HIV reservoirs remain the primary barrier to achieving a functional cure. Current latency-reversing agents (LRAs) have shown limited clinical utility because most rely on NF-κB signaling, which triggers widespread immune activation and inflammatory cytokine release, creating safety concerns...

Published: 11/5/2025 | Inventor(s): Alberto Bosque-Pardos, Shingo Kitamura, Elyse McMahon

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Category(s): Technology Classifications > Therapeutics > Repurposed Drugs, Technology Classifications > Therapeutics > Small Molecules