Search Results - elisa+tomat

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Synthesis of Novel Au(II) Dimers and Investigation of their Potential for Applications in Cancer Treatment

This invention is a method of synthesis of novel Au(II) dimer with pyridine dipyrrolinone (H2PYDP) ligands which demonstrate antiproliferative activity in ovarian cancers. This compound operates with a different mechanism than similar existing drugs allowing for novel combinational drug therapies to be created and tested. Background: It is estimated...

Published: 7/8/2024 | Inventor(s): Elisa Tomat, Iva Habensus, Yu-Shien Sung

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Category(s): Technology Classifications > Life Sciences > Therapeutics, Technology Classifications > Healthcare Portfolios > Oncology, Technology Classifications > Healthcare Portfolios > Women's Health

Redox-Activated Pro-Chelators

Novel molecular design extends the reach of iron chelators to applications in cancer chemotherapy. This invention not only recognizes the higher demand of iron that characterizes cancer cells, but also takes into account other physiological differences between malignant cells and the surrounding tissue. Specifically, pro-drugs are designed to activate...

Published: 3/12/2024 | Inventor(s): Elisa Tomat, Eman Akam, Yu-Shien Sung

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Category(s): Technology Classifications > Life Sciences > Small Molecules, Technology Classifications > Life Sciences > Therapeutics, Technology Classifications > Healthcare Portfolios > Blood & Lymphatic Disease, Technology Classifications > Healthcare Portfolios > Oncology

Iron Targeting to Halt Proliferation in Malignant Cells

This invention comprises a class of tetrazolium-based prochelators for targeting and binding intracellular iron and thereby interfere in cancer cell proliferation or other iron dysregulation. The redox potential of various analogues within this class of compounds can be tuned for targeting of cancer cells. Following cellular uptake, the tetrazolium...

Published: 3/12/2024 | Inventor(s): Elisa Tomat, Yu-Shien Sung

Keywords(s):

Category(s): Technology Classifications > Healthcare Portfolios > Oncology, Technology Classifications > Life Sciences > Therapeutics

Iron-targeting to stop cancer growth in malignant cells

This invention comprises a class of tetrazolium-based prochelators for targeting and binding intracellular iron for selective cancer cell antiproliferation or other iron dysregulation. Various analogues within this class of chemistry can be tuned to the redox potential for selective targeting of cancer cell types. Following cellular uptake, the tetrazolium...

Published: 3/12/2024 | Inventor(s): Elisa Tomat, Zoufeng Xu

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Category(s): Technology Classifications > Healthcare Portfolios > Oncology, Technology Classifications > Life Sciences > Therapeutics, Technology Classifications > Life Sciences > Small Molecules, Technology Classifications, Technology Classifications > Healthcare Portfolios > Neurology > CNS & Neurosciences

PMU-Embedded Analytics for Online Event Detection and Classification in Power Grids

The energy requirement of the world is increasing exponentially every year. With the power demand sites concentrated in the region with the highest population density, energy production sites must be located remotely. This isolation requires lengthy and complicated grids to be designed and manufactured to transmit power over long distances. Grid failures...

Published: 7/30/2024 | Inventor(s): Payman Dehghanian, Shiyuan Wang, Li Li

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Category(s): Technology Classifications > Industrial or Consumer Tech > Energy Infrastructure and Environment

New Libraries of Disulfide Prochelators and Application of Treating Metal Ion Disregulation

Published: 6/20/2024 | Inventor(s): Elisa Tomat

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Category(s): Technology Classifications > Healthcare Portfolios > Ophthalmology, Technology Classifications > Life Sciences > Therapeutics

Intracellular Reduction/Activation of a Disulfide Switch in Thiosemicarbazone Iron Chelators

Published: 3/12/2024 | Inventor(s): Elisa Tomat

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Category(s): Technology Classifications > Life Sciences > Therapeutics

Disulfide-Masked Prochelators for Intracellular Metal Sequestration

A novel pro-drug compound is activated into an iron chelating agent within the reducing environment of the cytoplasm of cancer cells. This invention provides enhanced selectivity to target cancer cells as compared to previous iron chelation approaches. This invention not only recognizes the higher demand of iron that characterizes cancer cells, but...

Published: 6/20/2024 | Inventor(s): Elisa Tomat, Eman Akam

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Category(s): Technology Classifications > Life Sciences, Technology Classifications > Life Sciences > Therapeutics

Glycoconjugates of Antiproliferative Iron Pro-Chelators Targeting Cancer Cell Metabolism

This technology provides novel glycoconjugates of antiproliferative iron pro-chelators that target the altered metabolism of cancer cells. The key to the success of chelation therapy in cancer treatment is the ability to target iron ions in malignant cells without affecting iron levels in the bloodstream and in normal tissues. Lacking such selectivity,...

Published: 3/12/2024 | Inventor(s): Elisa Tomat, Eman Akam

Keywords(s):

Category(s): Technology Classifications > Healthcare Portfolios > Oncology, Technology Classifications > Life Sciences > Therapeutics

Targeting Iron in Colon Cancer via Glycoconjugation of Thiosemicarbazone Prochelators

This invention is a novel strategy to create iron chelators by utilizing a disulfide redox switch to connect carbohydrate moieties to a thiosemicarbazone iron-binding unit. This increases expression of glucose transporters in colorectal cancer cells and greater toxicity to cancer cells. Background: An increased amount of iron in colorectal cancer...

Published: 3/12/2024 | Inventor(s): Elisa Tomat, Eman Akam

Keywords(s):

Category(s): Technology Classifications > Life Sciences, Technology Classifications > Healthcare Portfolios > Oncology

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