Search Results - donald+menick

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Electrically Conductive Nanomaterials Reinforced Cardiac Microtissues
Technology: Progenitor cells provide strong regenerative ability, but are limited by their immature phenotype and inability to generate functional tissues equivalent to adult cardiomyocytes. This technology provides a novel approach to successfully regenerate functional cardiomyocytes from progenitor cells. The strategy involves providing a physiologically-relevant...
Published: 3/22/2023   |   Inventor(s): Donald Menick, Ying Mei, Tan Yu, Dylan Richards, Bozhi Tian
Keywords(s):  
Category(s): BioPharma
Mitochondrial targeted HDAC inhibitors for the treatment of heart failure and related diseases and disorders (MitoDACs)
Technology: Researchers at MUSC have discovered HDAC1 is present in the adult cardiac myocyte mitochondria. A series of HDAC1 inhibitors that target mitochondria have been made (MitoDACs). One of the analogs, LL-66, localizes to the mitochondria and is absent from the nucleus in isolated adult rat cardiac myocytes. Inhibiting activity of HDAC1...
Published: 4/29/2024   |   Inventor(s): Donald Menick, Chung-Jen (James) Chou, Daniel Herr, Xiaoyang (李晓杨) Li
Keywords(s):  
Category(s): BioPharma
Improved Differentiation of Stem Cells into Cardiac Muscle Cells for Cardiac Tissue Repair
This approach advances the maturation of stem cells or progenitor cells, cells that differentiate like stem cells, to produce functional, biocompatible cardiomyocytes for the repair of damaged cardiac tissue. Cardiomyocytes are specialized cardiac muscle cells essential for cardiac muscle health. Cardiovascular disease, the leading cause of death worldwide,...
Published: 10/8/2024   |   Inventor(s): Ying Mei, Yu Tan, Dylan Richards, Donald Menick, Bozhi Tian
Keywords(s):  
Category(s): Biomedical Sciences