Search Results - dimitrios+morikis

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C3aR as Putative Target for Inflammation

Novel C3aR agonists and antagonists for inhibiting pro-inflammatory activities of the human complement system targeting C3aR Princeton Docket # 12-2813 Novel agonists to C3aR have been designed using a de novo design framework. The best predicted peptides were experimentally validated using a rat basophilic leukemia cell degranulation assay and...

Published: 3/30/2022 | Inventor(s): Christodoulos Floudas (DECEASED) See Fotini P. Baba, Meghan Bellows Peterson, Dimitrios Morikis, Peter Monk, Trent Woodruff

Keywords(s):

Category(s): Biotechnology/Pharmaceuticals

Compstatin Variants as therapeutic leads for Autoimmune and Inflammatory Disease

Princeton University Invention # 09-2488 The present invention relates to a series of novel analogues to compstatin. Based on experimental SPR (Surface Plasmon Resonance) and IC50 binding data these new analogues show greater binding affinity compared to native compstatin and are therefore potentially more potent drug candidates for diseases related...

Published: 3/30/2022 | Inventor(s): Christodoulos Floudas (DECEASED) See Fotini P. Baba, Meghan Bellows Peterson, Dimitrios Morikis

Keywords(s): small molecule, therapeutic

Category(s): Biotechnology/Pharmaceuticals

C3aR Antagonists

Princeton University Invention # 10-2571 Using a novel computation framework, researchers at Princeton University and the University of California, Riverside, have identified potent antagonists of the C3a receptor (C3aR). Inhibition of binding of C3a to C3aR is an excellent target for drug design against autoimmune and inflammatory diseases...

Published: 7/29/2024 | Inventor(s): Christodoulos Floudas (DECEASED) See Fotini P. Baba, Ho ki Fung, Meghan Bellows Peterson, Dimitrios Morikis, Chris Kieslich, Li Zhang

Keywords(s):

Category(s): Biotechnology/Pharmaceuticals