Search Results - david+alland

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Genetic Manipulation of Natural Killer Cells to Express c-MPL Growth Factor Receptor as a Therapy for Cancer
This technology includes genetic manipulation of natural killer (NK) cells to express thrombopoietin receptor (c-MPL) growth factor receptor as strategy to augment NK cell proliferation and anti-tumor immunity. Many investigational adoptive immunotherapy regimens utilizing NK cells require the administration of IL-2 or IL-15 cytokines to support the...
Published: 8/12/2024   |   Inventor(s): David Allan, Richard Childs
Keywords(s):  
Category(s): Application > Research Materials, Application > Therapeutics, Collaboration Sought > Licensing, ResearchProducts > Research Equipment, TherapeuticArea > Oncology
Bact-Builder
​ Invention Summary: Mycobacterium tuberculosis infects a quarter of the world's population and was the second leading infectious disease killer after SARS-CoV-2 in 2020. The H37Rv strain of M. tuberculosis is widely used in laboratory experiments, but current genome assembly tools are unreliable and lack consistency. Rutgers researchers...
Published: 8/5/2024   |   Inventor(s): David Alland, Poonam Chitale, Alexander Lemenze
Keywords(s):  
Category(s): Technology Classifications > Software & Algorithms, Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Software & Copyright
JSF-3285, A Novel KasA Inhibitor for Tuberculosis
Figure 1. Summary profile of JSF-3285: A) In vitro profile. B) X-ray crystal structure and binding constant for complex with KasA. C) In vivo profile in mouse chronic infection model. Invention Summary: New antibacterial drugs that treat multidrug resistant mycobacterium tuberculosis (MDR TB) represent an area of high medical need. The current tuberculosis...
Published: 7/26/2024   |   Inventor(s): Joel Freundlich, David Alland, Matthew Neiditch, Glenn Capodagli, Sean Ekins, Pradeep Kumar, Divya Awasthi, Daigo Inoyama
Keywords(s): Antibacterial
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics