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Search Results - autm26_1
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Compounds and methods for FBXW7-R465C-mediated protein degradation
NU 2024-224 INVENTORS Xiaoyu Zhang* Ananya Basu SHORT DESCRIPTION This invention describes novel heterobifunctional compounds that exploit a somatic mutant of the FBXW7 E3 ligase for targeted protein degradation. BACKGROUND Targeted protein degradation (TPD) is a powerful therapeutic strategy that harnesses the cell's natural machinery...
Published: 2/6/2026
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Inventor(s):
Keywords(s):
AUTM26_1
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Cancer/Oncology
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PROTAC
Category(s):
Life Sciences > Therapeutics
NU-CATS risk score for endometrial cancer prognosis
NU 2023-107 INVENTORS Shuhua Zheng* Eric Donnelly Jonathan Strauss SHORT DESCRIPTION Machine learning-based new unified risk classification score (NU- CATs) for patients with endometrial cancer. BACKGROUND Clinically relevant classification of endometrial cancer is important for prognosis and predictions of treatment success. Traditionally,...
Published: 2/6/2026
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Inventor(s):
Keywords(s):
Artificial Intelligence & Machine Learning
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AUTM26_1
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Cancer/Oncology
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Diagnostics
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Endometrial cancer
Category(s):
Life Sciences > Healthcare Devices, Tools & IT
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Physical Sciences > Software & Services
Compounds and methods of identifying novel E3 ligases for targeted protein degradation
NU 2023-096 INVENTORS Ananya Angela Basu Xiaoyu Zhang* SHORT DESCRIPTION A CRISPR-activation screen for discovering E3 ligases amenable to targeted protein degradation, and a novel PROTAC for FBXO22 BACKGROUND Traditional small molecule drugs function by directly interfering with the activities of proteins. However, many proteins lack suitable...
Published: 2/6/2026
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Inventor(s):
Keywords(s):
AUTM26_1
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Drug discovery
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Proteomics
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Small molecule
Category(s):
Life Sciences > Therapeutics