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High-Throughput Screening Assay for Novel Inhibitors of Penicillin Binding Proteins
Researchers at MUSC have developed a high-throughput assay that uses fluorescence polarization (FP) to distinguish the fluorescent penicillin, Bocillin-FL, in free or PBP-bound form. The assay can be used to identify new compounds that inhibit penicillin binding proteins (PBPs), which are proven targets for β-lactam antibiotics. This assay was...
Published: 9/25/2014   |   Inventor(s): Christopher Davies, Alena Fedarovich, Yuri Peterson
Keywords(s): infectious
Category(s): Therapeutic