Co-Assembly Strategy for the Formation of γ-Cyclodextrin-Containing Hybrid Frameworks

NU 2020-033

INVENTORS
J Fraser Stoddart*
Dengke Shen

SHORT DESCRIPTION
A novel protocol to produce a new kind of edible skincare formulation which is vapor-triggered sustained-released.

ABSTRACT
Northwestern researchers have developed a synthetic class of γ-cyclodextrin-containing hybrid frameworks (CD-HFs), employing γ-cyclodextrin (γ-CD) as the primary building blocks, along with 4-methoxysalicylate anions as the secondary building blocks. The CD-HFs are constructed through the synergistic exploitation of coordinative, electrostatic, and dispersive forces. The syntheses have been carried out using an organic counteranion co-assembly strategy, which allows for the introduction of 4-MS−, in place of inorganic OH−, into the cationic γ-CD-containing metal-organic frameworks (CD-MOFs).  This one-pot protocol for creating crystals with frameworks containing delivery system and the drug molecules, solves the problem of imprecise loading drug molecules by physical/chemical adsorption in the channels of the porous materials. Its addresses an unmet need for stabilizing the framework in water.

APPLICATION

• Skincare Formulation

ADVANTAGES

• Edible formulation for drug delivery
• Precise load of the drug in the delivery at molecular level
• Stable crystalline structure with the drug molecules as part of the frameworks in the crystal
• Water vapor-triggered sustained release

PUBLICATION
Shen D, Cooper J, Li P, Guo QH, Cai K, Wang X, Wu H, Chen H, Zhang L, Jiao Y, Qiu Y, Stern C, Liu Z, Sue A, Yang YW, Alsubaie F, Farha O and Stoddart JF (2020) Organic Counteranion Co-assembly Strategy for the Formation of γ-Cyclodextrin-Containing Hybrid Frameworks.  J. Am Chem Soc 142: 2042-2050.

IP STATUS
A US patent application has been filed.