Antibody against Endoplasmic reticulum lipid raft associated 2 (Erlin-2; also known as anti-NET32 and anti-SPFH2)
Background:
Erlin-2 (endoplasmic reticulum lipid raft associated 2) a member of the SPFH domain-containing family of lipid raft-associated proteins. The protein is localized to lipid rafts of the endoplasmic reticulum and plays a critical role in inositol 1,4,5-trisphosphate (IP3) signaling by mediating ER-associated degradation of activated IP3 receptors. Mutations in the Erlin2 gene are a cause of spastic paraplegia-18 (SPG18). Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Technology Overview:
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Applications: