Novel Scintillating Detectors for X-ray Imaging with Micron Resolution
Overview An x-ray detector is only as good as its image resolution. Our technology, which uses coherent bundles of scintillating fibers, provides a substantial increase in resolution over existing x-ray detector technologies.
Market Opportunity The usefulness of x-ray imaging’s many medical applications is limited by the image resolution. The x-rays currently used for mammography, for example, are 80–100 microns. The less than 10-micron resolution of x-rays produced with our technology will greatly improve the ability to discern malignancies. The greater resolution produced by our technology will also improve imaging in various scientific and engineering fields.
Innovation and Meaningful Advantages Our technology includes a methodology for creating coherent bundles of scintillating fibers, also known as glass capillary arrays, to significantly increase the resolution in x-ray detectors to the single-digit micron range. These coherent bundles of scintillating fibers are then placed opposed to a charge-couple device (CCD) camera or integrated with a complementary metal oxide semiconductor (CMOS) photodetector. Incident x-rays activate the scintillators in individual fibers, which emit visible light to the camera, which then generates an image. Because scintillator size is correlated with image resolution, the use of coherent bundles of small-diameter scintillating fibers greatly increases the maximum image resolution.
We intend to create these fibers by infusing a scintillator-embedded plastic into a plate with 3-15 micron-diameter pores. The pore walls have a highly reflective silver coating; a thin refractory buffer layer prevents deterioration of this coating. This reflective cladding structure maximizes photon yield in the pore structure. The bundles have slightly diagonal fibers, which enable four low-cost, high-resolution CMOS sensors to be grouped together, for a large active sensing area. This allows for high-resolution x-rays of large objects without the need for an expensive larger area CMOS detector.
Collaboration Opportunity We are interested in exploring 1) startup opportunities with investors in the medical imaging space; 2) research collaborations with leading medical imaging companies to further develop this technology; and 3) licensing opportunities with medical imaging companies.
Principal Investigator Angus I. Kingon, PhD Barrett Hazeltine University Professor of Entrepreneurship and Organizational Studies Professor of Engineering Brown University Brown Tech ID #2286, 3020 angus@brown.edu
IP Information 2014-03-06 US9611168B2; issued 2014-03-06 US10358376B2; issued 2014-03-06 US10399887B2; issued 2020-10-16 63/092651; provisional 2020-10-16 63/092,716; provisional
Publication Morse TD, Mostovych N, Gupta R, Murphy T, Weber P, Cherepy N, Adams B, Bifano T, Stankus B, Akif A, Kingon A. Demonstration of a high resolution x-ray detector for medical imaging. Proceedings, Radiation Detectors in Medicine, Industry, and National Security XIX. 2018 Sept. 11;10763. doi.org/10.1117/12.2320723.