THE CHALLENGE:
Continuous transdermal drug delivery is a critical area in biomedical engineering, particularly for managing chronic conditions such as diabetes, requiring the regular administration of medications like insulin. The demand for wearable, user-friendly devices that can provide consistent and reliable drug infusion is growing, driven by the need to improve patient compliance, enhance quality of life, and ensure precise control over therapeutic dosing. Effective transdermal systems offer the advantage of maintaining steady drug levels in the bloodstream, which is essential for managing diseases that require meticulous dosing schedules.
However, current approaches to continuous drug delivery face significant challenges. Traditional insulin pumps and similar devices often rely on electronic components, batteries, and external power sources, which can make them bulky, complex, and cumbersome for daily use. These systems typically require frequent maintenance, such as battery replacements and calibration, which can be inconvenient for users and limit their long-term reliability. Additionally, the dependence on power sources restricts the portability and ease of use of these devices, potentially leading to interruptions in therapy and reduced effectiveness. These limitations highlight the need for simpler, more efficient drug delivery solutions that overcome the drawbacks of existing technologies.
OUR SOLUTION:
The device is a sleek, wrist-worn microfluidic pump designed for continuous transdermal infusion of macromolecular drugs in liquid form. Comparable in size to a nicotine patch, it leverages the wearer’s radial pulse to drive fluid flow, eliminating the need for electronic components or external power sources. The system offers two operational modes: one that dynamically adjusts to changes in heart rate and blood pressure, and another that maintains a steady infusion rate regardless of physiological variations. It integrates seamlessly with 3D-printed microneedle arrays and reservoirs, facilitating the delivery of medications such as insulin, chemotherapy agents, and vaccines. Its user-friendly design ensures reliable long-term drug administration, making it suitable for a range of medical applications.
This technology stands out due to its unpowered functionality, which simplifies the device and enhances portability compared to traditional pump systems. By utilizing the wearer’s natural pulse, it negates the complexities and power requirements associated with electronic devices, offering a more sustainable and maintenance-free solution. Additionally, its versatile integration options allow for customization with various delivery mechanisms like microneedle arrays or cannulas, broadening its applicability across different therapeutic areas. The compact and disposable nature of the device positions it competitively against established medical device companies, while its potential for continuous, reliable drug delivery without external power sources provides a significant advantage in the medical device market.
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POTENTIAL APPLICATIONS: