In this invention, an external stimulus is applied to the stationary phase of liquid chromatography to alter the polarity of the solvent during a separation process. This capability enables improved separations with more efficient use of mobile phase. The chromatographic separation method can be designed with flexible equipment and machine learning.
Background:
Chromatography is a well-established process and is widely used for laboratory chemical separation; however, it is problematic for large scale use. Enhancements in separation efficiency will be useful to many areas of research and industry including:
Applications:
Advantages: