PAGE TITLE
Overview
PAGE SUMMARY
Drexel researchers have shown that non-thermal dielectric barrier discharge (DBD) plasma treatment is a viable method for reducing herpes simplex virus infection and replication without significantly affecting host cells, making it an ideal treatment for herpes keratitis of the cornea.
APPLICATIONS
TITLE: Applications
Preventing and treating herpes keratitis of the cornea.
ADVANTAGES
TITLE:Advantages
Non-drug method proven to suppress HSV replication and viral presence. Exposure of HSV-infected human corneal epithelial cells to media treated with non-thermal DBD plasma resulted in a reduced buildup of toxic viral proteins and overall reduced viral replication.
Alternative treatment option or combination therapy. Non-thermal plasma treatment operates unlike existing antivirals, allowing it to be used as a supplement or even to replace them where drug-resistant strains are present.
Little side effects. Toxicology studies have shown no lasting effects on normal cell proliferation and corneal health.
IP STATUS
Intellectual Property and Development Status
United States Patent Pending- 15/024,051
http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=/netahtml/PTO/srchnum.html&r=1&f=G&l=50&s1=20160206737.PGNR.&OS=DN/20160206737&RS=DN/20160206737
PUBLICATIONS
References
Pubinfo should be the citation for your publication. Publink is the full url linking to the publication online or a pdf.
Alekseev O, Donovan K, Limonnik V, and J Azizkhan-Clifford (2013). Non-Thermal Dielectric Barrier Discharge (DBD) Plasma Suppresses Herpes Simplex Type 1 (HSV-1) Infection of Corneal Epithelium. TVST.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3969218/
Commercialization Opportunities
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Contact Information
Robert McGrath
Sr. Associate Vice Provost
215-895-0303
rbm26@drexel.edu