USF researchers have assessed if human umbilical cord blood cells (hUCBCs)transplantation combined with the growth factor G-CSF afforded enhanced neuroprotection in an animal model of moder-ate TBI in the long term. Synergistic effects of hUCB transplantation and G-CSF treatment were discovered as evidenced by effective reduction in cell loss, robust reduction in neuroinflammation, and massive neuron generation in the TBI brain compared to stand alone therapies. This technology could be extended to use many different sources of stem cells. The method of treatment developed here will be beneficial after the diagnosis of a neurodegenerative disorder, autoimmune disease, or traumatic neuronal injury.
Combined therapy of human umbilical cord blood cells and G-CSF reduces inflammation in the brain compared to monotherapy