Noroviruses (also known as Norwalk viruses) are believed to cause approximately 90% of epidemic nonbacterial outbreaks of gastroenteritis worldwide and may be responsible for 50% of all foodborne outbreaks of gastroenteritis in the US. The CDC estimates that up to 200,000 children under the age of 5 die of norovirus infection in developing countries each year. There is no vaccine against norovirus and no specific antiviral drugs to treat infections.
Researchers at the Biodesign Institute of Arizona State University have developed a subunit antigen consisting of norovirus virus-like particles stabilized by a polysaccharide-containing plant extract. The virus-like particles have enhanced mucosal immunogenicity, and when delivered intranasally, the preparation causes a robust mucosal immune response without the need for adjuvants to trigger innate immune responses.
This nasal vaccine induces both mucosal and systemic immune responses while providing protection from two dominant norovirus genotypes; it also overcomes the storage and administration shortcomings of the current norovirus oral vaccines.
Potential Applications
Benefits and Advantages
For more information about the inventor(s) and their research, please see Dr. Arntzen's directory webpage Dr. Arntzen's departmental webpage