USF researchers have determined that administration of the bioactive lipid sphingosine-1-phosphate (S1P) can help stabilize arterial blood flow and blood pressure in alcohol-intoxicated trauma patients. Their findings also proposed that using agents that increase S1P or other S1P receptor agonists decrease alcohol-induced microvascular hyper-permeability. This discovery not only facilitates recovery efforts in alcohol-intoxicated trauma patients, but may assist with resuscitation efforts in hemorrhage trauma patients as well.
Blood Vessel Leakage Reduced by S1P Treatment in Alcohol-Intoxicated Rats