USF researchers have developed the first miRNA-based strategy to selectively inhibit VSMC proliferation and migration for the prevention of restenosis, without concurrently inhibiting reendothelialization and EC function. This was achieved by the design of a novel vector that inhibits VSMCs and selectively preserving ECs. This vector was shown to reduce hypercoagulation and restore EC function in vivo. The combination of a better stent platform and biodegradable polymer with this novel strategy, has the potential to revolutionize the future of vascular interventional medicine.
Novel Vector Reduces Hypercoagulability and Restores EC Function In Vivo