Rapid Regulation of Local Temperature with Wide-Field Plasmonic Thermal Microscopy

Temperature is a critical parameter for cellular activity regulations. Common temperature control techniques for cellular analyses utilize heating sources, which are often nonuniform over the target surface and time consuming. Plasmonic absorption of light, has been shown to be efficient in regulating localized heat rapidly and feasibly. It can be used to facilitate many practical applications such as photothermal therapy, neuron activation, phase separation, gas sensing and heterogeneous catalysis. However, plasmonic heating doesn’t provide uniform temperature regulation in a wide field.