Pseudoprolines in Neuropeptides

This invention describes the use of pseudo peptides to cross the blood-brain barrier and bind to targeted receptors to achieve pharmaceutical effects.

Background:
Increased research has led to the exploration of peptides delivering compounds by diffusing across the blood-brain barrier. Many peptide-based drugs are not created using pseudo-peptides, however, glycosylation plays a key role in manipulating the structure of existing peptides. This invention uses glycosylation to create a newly folded peptide that can then be used in a variety of pharmaceutical applications to produce medicinal effects.

Applications:

• Targeted drug delivery
• Biosensors
• Diagnostic imaging

Advantages:

• Increased capability to cross the blood-brain barrier
• Increased affinity to bind to specific targeted receptors
• Breakdown of the compound may not yield any toxic effects