Progressive Supranuclear Palsy Rating Scale (PSPRS)

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   Changes in Scores of PSP patients Over Time

Invention Summary:

Progressive Supranuclear Palsy (PSP) is a rare neurodegenerative disease that involves the gradual deterioration of the brain that leads to loss of balance, difficulty walking, vision problems and cognitive impairment.

The Progressive Supranuclear Palso Rating Scale (PSPRS) developed by Rutgers researcher, Dr. Lawrence Golbe, MD, measures the severity of impairment in patients with PSP. The rating system provides a quantitative measure of disability across 28 items in 6 primary domains of clinical impairment. Each item has its own scoring rubric ranging from 0-2, or 0-4 which is than tallied and compared to previous “milestones” through a given period of observation. Each item has specific guidelines for consistent administration. Furthermore, the PSPRS can be administered in less than 20 minutes within a clinician’s office. This scale offers valuable insight into the progression of PSP in patients. Dr. Golbe has also created instructional videos demonstrating each assessment to provide consistency and reliability to the PSPRS over multiple studies.

Market Applications:

• A tool for quantitative evaluation of patients’ impairment caused by PSP
• Rating scale can be used in clinical trials, and for assessment of patients in clinical or hospital settings.

Advantages:

• Able to measure disability across 28 items in six domains, including: daily activities, behavior, bulbar, ocular motor, limb motor, and gait/midline in less than 20 minutes
• Best statistical power compared to other clinical scale for PSP due to low intra-subject variability gives this
• Multiple language translations with certificates available upon request.
• Instructional videos of rating scale being administered are available for licensing. See: https://techfinder.rutgers.edu/tech?title=PSP_Rating_Scale%3a_Instructional_Video

Publications: •  DOI: 10.1093/brain/awm032

Intellectual Property & Development Status: Available for non-exclusive licensing; rating scale and videos can be licensed separately or together.  Special privacy methods required for access to videos. For any business development and other collaborative partnerships contact:  marketingbd@research.rutgers.edu