Title:
Inhibitors of HSV Nucleotidyl Transferases and Uses Therefor
Category:
Therapeutic
NCS:
Inventors: John E. Tavis and Lynda A. Morrison
Summary:
This invention discloses that inhibitors of nucleotidyl-transferase superfamily enzymes from multiple different chemical classes profoundly suppress replication of HSV-1 and HSV-2 with no measurable toxicity in a short-term cell culture assay. Inhibition by these primary screening hits may already be superior to currently approved drugs for herpes virus infection, such as acyclovir. The test data indicate that the compounds inhibit at least two different steps of the viral infectious cycle.
Patent: U.S. patent application 61/908,251
Manager:
Stephanie Kimzey, MBA