Polymerization of Lipid Assemblies in Aqueous Solution at Neutral pH

This invention is a novel method to induce radical polymerization in lipids in a neutral pH environment, preserving protein bioactivity. It utilizes a different set of reagents than a typical radical polymerization. This invention provides compounds comprising a triazenylidene moiety and methods for producing and using such compounds.

Background:
Normally, polymerization of lipids involves the production of acidic side products. Acidic conditions usually compromise protein bioactivity, rendering them useless when combined with the polymer.

Advantages:

• Neutral pH is safer to operate in than acidic pH
• Protein bioactivity is retained, allowing proteins to be used in conjunction with lipid polymers
• Lipid polymers make for stable compounds in vivo
• Safer and more efficient way of producing cross-linked lipid assemblies
• Preserves protein function of any proteins incorporated into the assembly

Application:

• Potential advanced drug delivery system 
• Can be used for theranostic purposes to image potential tumors in real time
• Cancer theranostics

Status: issued U.S. Patent #10,576,456