Our inventors have synthesized an ambient-light stable photo-label without compromising the photo-activated insertion reactivity. The new synthesized photo-label is effective for photo-affinity labeling techniques and shows significant aqueous solubility. This invention is a significant improvement over current photo-affinity labeling reagents, and will prove useful for drug discover and studying molecular interactions.
Comparison of Ambient Light Stability of Modified Trifluoromethylaryl Diazirines 1 and 2 Versus the Conventional Trifluoromethylphenyl Diazirine 3