Pathlength Resolved Diffuse Correlation Spectroscopy

Advantage

 

  • Accurate deep tissue monitoring eliminates guesswork in critical clinical assessments
  • One device replaces multiple instruments for complete physiological measurements
  • Affordable off-the-shelf components significantly reduce overall system cost
  • Reliable high quality signals are maintained even at safer lower laser powers

Summary

Clinicians monitoring tissue perfusion in critical areas like the brain or deep muscle beds face a fundamental measurement gap. Conventional optical techniques are dominated by superficial tissue signals, limiting depth sensitivity and masking the deep-tissue dynamics that matter most. Separate instruments are needed for blood flow and optical property measurements, driving up cost and complicating workflows, while high laser intensities required for deeper penetration risk exceeding safety thresholds.

This technology reimagines Diffuse Correlation Spectroscopy using a low-coherence continuous-wave light source within an interferometer configuration, precisely isolating specific tissue depths through coherence gating. Unlike conventional systems, it simultaneously measures blood flow indices alongside tissue absorption and scattering coefficients in a single instrument, penetrating beyond three centimeters at lower, safer laser powers. Built from cost-effective components and designed to integrate with existing systems, it delivers comprehensive deep-tissue physiological monitoring without the complexity, cost, or calibration burden of traditional approaches.

 

A Standard DCS Measurement

Desired Partnerships

  • License
  • Sponsored Research
  • Co-Development
Patent Information:
Title App Type Country Serial No. Patent No. File Date Issued Date Expire Date
Pathlength Resolved Cw-Light Source Based Diffuse Correlation Spectroscopy Nationalized PCT United States 18/029,649 12,569,154 9/28/2021 3/10/2026 9/28/2041