The surgical adhesives are an alternate simple method to the wound closure with less pain to patients. The inventors here have developed new materials to close the wound using photochemical process. Photochemical tissue bonding (PTB) process is where collagen fibers are crossed linked with minimal heat generation through irradiation of green laser (532 nm). There should be minimal heat generation under the PTB process otherwise it will decay the tissues. The invention uses two classes of PTB precursor materials that are used in combination to develop suture-less tissue bonding. This composition will dissolve in blood within ten minutes to one hour.
The images shows the healing of wound using PTB based hydrogel precursor.