Suturing is a standard procedure for closing wounds. Alternative suture‑less methods for wound closure reduce wound inflammation and allow patients to experience less pain when undergoing the reconnecting and sealing of tissues.
The inventors here have developed new materials to close the wound using photochemical tissue bonding (PTB) process. The PTB process is where collagen fibers are crossed linked with minimal heat generation through irradiation of green laser (532 nm). This invention developed a novel method and compositions for suture‑less wound closure for the PTB process. It uses a composition of PTB precursor materials that are used in combination to facilitate suture-less tissue bonding. It comprises: a poly(ethylene glycol) functionalized with photocrosslinkable groups, a hydroxy-modified chitosan, and a photochemically active dye. This composition is predicted to dissolve in blood within ten minutes to one hour. Further provided is a wound treating kit.
The images shows the healing of wound using PTB based hydrogel precursor.