Non-Invasive Closed-Loop Diaphragmatic Pacer for SUDEP Prevention

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Invention Summary:

Epileptic seizures can cause central respiratory arrest, a phenomenon called Sudden Unexpected Death in Epilepsy (SUDEP) which needs immediate respiratory support within 3 minutes to avoid death. The absence of reliable biomarkers further limits preventive measures to avoid SUDEP. Here, a wearable diaphragmatic pacer that non-invasively detects and prevents sudden unexpected death in epilepsy by stimulating breathing during seizures.

Rutgers researchers have developed an innovative technology that provides a non-invasive solution to sudden unexpected death in epilepsy (SUDEP) by using a closed-loop system that monitors breathing, detects respiratory arrest during a seizure, and stimulates the phrenic nerve via skin-level electrodes to induce diaphragm contractions and resume breathing. Unlike traditional implants, this device employs wearable cutaneous electrodes embedded in a garment, improving safety and accessibility. Proven effective in preclinical mouse models, it offers ventilatory assistance without requiring surgical implantation, using intelligent seizure detection and precise electrical stimulation to ensure efficient intervention only when needed.

Market Applications:

• Non-invasive design eliminates risks tied to surgery and implanted electrodes.
• Closed-loop system ensures real-time monitoring and responsive respiratory support.
• Wearable and user-friendly, enhancing patient comfort and compliance.
• Potential to prevent both fatal and non-fatal respiratory complications related to seizures.
• Eliminates risks and maintenance burdens of surgically implanted diaphragmatic pacemakers.

Advantages:

• Wearable medical garments for epilepsy patients with seizure-induced respiratory risks.
• Diaphragm pacing therapy systems for respiratory support during neurological events.
• Respiration sensor markets requiring integrated detection and intervention solutions.

Publications:

• Diaphragmatic pacing for the prevention of sudden unexpected death in epilepsy. Brain Commun. 2022 https://doi.org/10.1093/braincomms/fcac232  

Intellectual Property & Development Status: PProvisional patent application filed. Available for licensing and/or research collaboration. For any business development and other collaborative partnerships contact marketingbd@research.rutgers.edu.