New method for biosynthesis of hydroxylated polymethoxyflavones

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The potential benefits of hydroxylated polymethoxyflavones

Invention Summary:

Hydroxylated polymethoxyflavones (OH-PMFs), are a class of novel flavonoid compounds found in citrus plants with very low abundance. OH-PMFs could be produced through semi-chemical or semi-bio synthesis from their PMF counterparts, but the technique to generate OH-PMFs with OH substitution at 6 or 7 position is very limited. There is a need for more sustainable method to produce OH-PMFs, especially 6- or 7- OH-PMFs, at a higher yield.

      Rutgers researchers have developed a method for the biosynthesis of a variety of OH-PMFs, via the cultivation of a strain of yeast found in old orange peel. Combining with an innovative dispersion method, the process can be done in aqueous solution, with a high production yield and no need of complex purification.

Advantages:    

• Environmentally friendly
• Obtaining a multi-beneficial organic product by directly applying orange peel for fermentation using the new strain yeast
• Feasible for a variety of PMFs
• High yield

Market Applications:    

• OH‐PMFs have potential applications in the pharmaceutical industry as pharmaceutical agents, antioxidants, colorants, and cosmetics.
• Potential therapeutic treatment for central nervous system, hyperlipidemia, obesity, diabetes, cardiovascular disfunction and several types of cancer.
• The newly obtained OH‐PMFs could be used as standards for metabolic studies of PMFs, which would allow discerning the metabolic pathways in human body.

Intellectual Property & Development Status: 

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