USF researchers have developed an innovative method to disrupt amyloid aggregation for the treatment of neurodegenerative diseases and related disorders. This invention includes the synthesis and development of short N-aminated peptides. These backbone aminated peptides mimic beta-sheet protein secondary structure and effectively disrupt beta-sheet association and aggregation events important in the progression of Alzheimer's disease, Parkinson's disease, and other related diseases.
A Visual Example Showing the Effects of Alzheimer’s Disease (AD) on Brain Matter